Welcome to 2011 from the editorial staff of Current Rheumatology Reports! As Henry David Thoreau eloquently stated, “Could a greater miracle take place than for us to look through each others eyes for an instant?” While the eyes are a fascinating window into the systemic manifestations of rheumatic diseases, a surprising lack of awareness of the ocular manifestations of rheumatic diseases exists. In this issue of the journal, we attempt to correct this discrepancy by presenting several expertly written articles on the topic. I am sure that the readership will find great practical value in these wonderful articles and I invite you to provide any comments or vignettes that come to mind. In the second part of this issue, we present thought provoking articles about issues that come up in the treatment of rheumatoid arthritis with biologic agents. The issue of whether biologic agents increase the risks for cancer and infection has been debated since the advent of the biologic era. While no consensus has been achieved on these topics, Drs. Bongartz and Finckh provide us with an uptodate review of the literature. Dr. De Keyser tackles the question of failure of a TNF blocker and provides expert guidance in this often encountered clinical scenario. We look forward to your continued readership.