The Aging of the Adaptive Immune System

Author(s): Dietmar Herndler-Brandstetter, Birgit Weinberger, Gerald Pfister, Daniela Weiskopf, Beatrix Grubeck-Loebenstein.

Journal Name: Current Immunology Reviews

Volume 7 , Issue 1 , 2011

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Abstract:

Adaptive immune responses are severely affected by the aging process as reflected by an increased morbidity and mortality from infectious diseases and a low efficacy of vaccination in elderly persons. Age-related changes within the bone marrow and thymus lead to an impaired generation of new T and B cells severely compromising the maintenance of a diverse and balanced T and B cell repertoire in old age. The maintenance of a balanced T cell repertoire is further challenged by latent persistent infections, such as Cytomegalovirus. Understanding the mechanisms of age-related alterations of the adaptive immune response may help to facilitate the development of more efficient vaccines for elderly persons and to envisage strategies to overcome immunosenescence.

Keywords: Aging, T cell, B cell, cytomegalovirus, Th17, Treg

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2011
Page: [94 - 103]
Pages: 10
DOI: 10.2174/157339511794474190

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