Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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The Global Component-Target Network in Panax Ginseng C

Author(s): Fan Zhang, Chun-Yang Li, En-Qin Wang, Wen-Wen Li, Qi-Jia Yu, Xin Wen, Jun-Jie Liu, Jin-Ku Bao.

Abstract:

Panax ginseng C. A. Meyer (PG), a well-known traditional Chinese medicine, has been widely used as a panacea in treatment of human diseases for a long time. In this study, we exerted systems biology and bioinformatics methods for the first time and analyzed the “giant components” of PG in the global component-target interaction network. Based upon this network, we further confirmed several key components and their related targets (e.g., NF-κB, COX-2, Bax, NOS, JNK, p21 and MMP3). Additionally, we demonstrated that ginsenosides and key targets were involved in several cancer-related pathways, which indicated that ginsenosides might play crucial roles in cancer treatments. Interestingly, we also found that the component-target network might provide new clues for further predicting new targets and elucidating the relationships amongst the network and side-effects. In conclusion, these inspiring findings demonstrate that the versatile effects of PG are mostly ascribed to the comprehensive interactions amongst ginsenosides and their pivotal targets.

Keywords: Panax ginseng C. A. Meyer, Ginsenoside, Network, NF-B, Cancer, Drugs, bioinformatics, phytosterols, peptides, polysaccharides, fatty acids, polyacetylenes, vitamins, minerals, Cytoscape, cytokines, ultraviolet irradiation, heat shock, osmotic shock, Matrix metalloproteinase-3, immunoregulation, Bcl-2-associated X protein, Traditional Chinese Medicine, c-Jun N-terminal kinases, Nuclear Factor kappa B, Cyclin-dependent kinase inhibitor 1

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2011
Page: [181 - 188]
Pages: 8
DOI: 10.2174/157018011794183842
Price: $58