Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Heterocyclic Compounds as MDR Modulators

Author(s): Gyorgy Hajos, Katalin Jemnitz, Zsuzsanna Riedl, Daniella Takacs, Zsuzsa Veres.

Abstract:

A survey on MDR modulators containing heterocyclic moiety in the chemical structure for the past 20 years is provided. The discussion of the particular active compound is classified according to the heterocyclic rings involved. The most important biological results are also summarized.

Keywords: MDR modulation, Heterocyclic, Imidazole, Quinoline, Tetrahydroisoquinoline, Phenothiazine, multidrug resistance (MDR), Pglycoprotein (P-gp), protozoan parasite, Nbenzylpiperazine, doxorubicin, 99mTc-tetrofosmin, fluorescence activity, paclitaxel, vincristine, colon carcinoma, cruciferous vegetables, fumitremorgin, mitoxanthrone, tissue polypeptide antigen-A, rhodamine, cyclosporine, tariquidar, anthranylamine, zosuquidar, severe combined immunodeficient (SCID), C6 glioblastoma cell, clomipramine, piperazine, dioxaphosphinane

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2011
Page: [102 - 113]
Pages: 12
DOI: 10.2174/157018011794183815
Price: $58