Novel synthesis of putaminoxin, stagonolide-F and aspinolide-A have been achieved by utilizing (S) and (R)- malic acid. The key feature of the synthetic strategy includes Horner-Wittig olefination, double bond reduction and Steglich esterification. Olefinic acid for putaminoxin and stagonolide-F was prepared from (S)-malic acid whereas olefinic acid for aspinolide-A was prepared from (R)-malic acid and olefinic alcohols for putaminoxin, stagonolide-F and aspinolide-A were prepared by using Browns asymmetric allylboration.
Keywords: Decanolides, (S) and (R) malic acid, Horner-Wittig olefination, Steglich esterification, Brown's asymmetric allylboration, Ring closing metathesis (R.C.M.), microcarpalide, Stagonolide-F, putaminoxin, butyraldehyde
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