One-Pot Synthesis of Furans from Isoxazolines with Iron as Reducing Agent

Author(s): Dahong Jiang, Yuanwei Chen.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 8 , 2010

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Abstract:

A highly efficient route to substituted furans from readily available 5-hydroxymethyl-substituted Δ2- isoxazolines is described. The transformation involves sequential reduction/hydrolysis/cyclocondensation in a one-pot reaction using iron as reducing agent under mild conditions.

Keywords: Furan, isoxazoline, iron, reduction, optoelectronic, natural products, cyclocondensation, catalytic hydrogenation, 2-isoxazolines, hydroxy ketones, N, –, O bond cleavage, hydroxyimine, cyclodehydration, HCl, HOAc, reaction temperature, vinyl groups, acetic acid, solvents, NMR, CDCl3, MgSO4

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Article Details

VOLUME: 7
ISSUE: 8
Year: 2010
Page: [661 - 665]
Pages: 5
DOI: 10.2174/157017810793811722
Price: $65

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