Synthetic Studies of Superstolide A: A Carbohydrate Based Synthesis of the C21-C26 Segment

Author(s): Rita Pal, Hasibur Rahaman, D. K. Mohapatra, Mukund K. Gurjar.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 8 , 2010

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Abstract:

The synthesis of C21-C26 fragment of superstolide A, starting from D-glucose diacetonide, involving regioselective ring opening of epoxide by Grignard reagent and regioselective stereospecefic hydroboration oxidation has been described.

Keywords: Superstolide A, Potent cytotoxic, Chiral pool, Regioselective epoxide opening, Stereoselective hydroborationoxidation, Carbohydrate, C21-C26, Grignard reagent, Neosiphonia superstes, polyketide, D-glucose diacetonide, hydroboration oxidation, tosylation, alcohol, epoxidation, benzyl ether, Cleavage, methanolic HCl, hydroxyl group, Oxidative cleavage, CuCN, PDC oxidation, selectively, Debenzylation, BBN, PMB, mesylation, azido, compound

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Article Details

VOLUME: 7
ISSUE: 8
Year: 2010
Page: [657 - 660]
Pages: 4
DOI: 10.2174/157017810793811704
Price: $65

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