Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Evaluation of Antimicrobial Activity of Thiazolidinone Derivatives

Author(s): Ravichandran Veerasamy, Harish Rajak, Krishnan Suresh Kumar, Ram Kishore Agrawal.


A series of 1,3-thiazolidin-4-one derivatives were prepared by the reaction of respective aromatic amine, aromatic aldehyde and thioglycolic acid in dry benzene/toluene. The newly synthesized compounds were characterized on the basis of elemental analysis, IR, 1HNMR and mass spectra. The newly synthesized final compounds were evaluated for their in-vitro antibacterial, antifungal and anti-viral activities. Preliminary results indicated that most of the compounds demonstrated moderate to good antimicrobial activity, comparable to standard drugs. Structure – activity relationship studies revealed that the nature of the substituents at the 2nd and 3rd positions of the thiazolidinone nucleus had a significant impact on the in-vitro antimicrobial activity of this class of potent antimicrobial agents.

Keywords: Thiazolidinones, Antibacterial, Antifungal, Anti-viral, Schiff's reaction, Antimicrobial, nucleoside, NNRTIs, TBZs, SAR, anti-HIV, MT-4 cells, TBZ, minimum inhibitory concentrations, TLC, DMSO, CHCl3, FAB-MS, Cytotoxicity, influenza A H3N2, MDCK, KOS, EC50, CC50

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Article Details

Year: 2011
Page: [82 - 86]
Pages: 5
DOI: 10.2174/157018011793663958