Study on the Langmuir Aggregation of Sodium Octanesulfonate on Human Serum Albumin

Author(s): Ling Li, Zu Shun Xu, Gong Wu Song.

Journal Name: Protein & Peptide Letters

Volume 18 , Issue 1 , 2011

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Abstract:

The microphase adsorption-spectral correction (MPASC) technique was described and applied to the study of the interactions of sodium octanesulfonate (SOS) with human serum albumin (HSA). The aggregation SOS obeys the Langmuir monolayer adsorption. The results show the adsorption ratio of sodium octanesulfonate to HSA is SOS:HSA=18:1. The adsorption constant is KSOS-HSA=4.03×102. The detection limit is 0.036μmol/L. FT-IR spectra proved the binding changed the conformation of HSA.

Keywords: Surfactant, human serum albumin, langmuir aggregation, Langmuir, Octanesulfonate, Serum Albumin, amphiphilic, hydrophilic, thermodynamic response, protonated, electrostatic film, microelectrostatic, monolayer, plotting -1, peak wavelength 2, endogenous, Spectrophotometer, vortex mixer, analytical-reagent grade, biotechnology, colorimetric tube, calcium fluoride wafer, Fluorescence Enhancement, synchronous, tyrosine, tryptophan, monochromator, critical micell concentration, CMC, versus Cs-1, regression equation, phenomena, fixed concentration, enhancement effect, straight line, Thermodynamic, enthalpy change, Hoff equation, Stern, –, Volmer, perturbing effects, quantum yield, Trp residues, (MPASC) technique, Organic Function MoleculesSurfactant, human serum albumin, langmuir aggregation, Langmuir, Octanesulfonate, Serum Albumin, amphiphilic, hydrophilic, thermodynamic response, protonated, electrostatic film, microelectrostatic, monolayer, plotting -1, peak wavelength 2, endogenous, Spectrophotometer, vortex mixer, analytical-reagent grade, biotechnology, colorimetric tube, calcium fluoride wafer, Fluorescence Enhancement, synchronous, tyrosine, tryptophan, monochromator, critical micell concentration, CMC, versus Cs-1, regression equation, phenomena, fixed concentration, enhancement effect, straight line, Thermodynamic, enthalpy change, Hoff equation, Stern, –, Volmer, perturbing effects, quantum yield, Trp residues, (MPASC) technique, Organic Function Molecules

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Article Details

VOLUME: 18
ISSUE: 1
Year: 2011
Page: [1 - 6]
Pages: 6
DOI: 10.2174/092986611794328672

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