Recent Advances and Future Perspectives of Triazole Analogs as Promising Antiviral Agents

Author(s): Rajeev Kharb, Mohammad Shahar Yar, Probodh Chander Sharma.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 11 , Issue 1 , 2011

Become EABM
Become Reviewer

Abstract:

Emergence of severe viral infections in recent years and limited availability of antiviral chemotherapeutic agents for prevention and treatment of these infections are among the most common causes of human illness and death. Therefore, there is an urgent need to develop antiviral drugs that have a potentially critical role in the prevention and treatment of various fatal and debilitating viral infections. Triazole derivatives occupy a pivotal position in modern medicinal chemistry and several have found applications as medicines. A large volume of research has been carried out on triazole and their derivatives for antiviral activity and pharmacological importance of this scaffold has been well established. This review is primarily addressed to description of the recent advances in the synthesis and evaluation of triazole derivatives as antiviral agents which may facilitate the development of more potent and effective antiviral agents.

Keywords: Antiviral activity, HAART, ribavirin, 1,2,3-triazole, 1,2,4-triazole, tobacco mosaic virus, AIDS, HIV, H1N1, Triazole, respiratory syncytial virus (RSV), infection, hepatitis C infection, Lassa fever, Crimean-Congo hemorrhagic fever, efavirenz, nevirapine, MDBK, BVDV, BHK, Reo, pseudo-type HIV assay, BSC-40 cells, Western Blots, amantadine, ISRE, HFRS, ETAR, zanamivir, ACVR, trovirdine, didadosine

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 11
ISSUE: 1
Year: 2011
Page: [84 - 96]
Pages: 13
DOI: 10.2174/138955711793564051

Article Metrics

PDF: 22