A Novel Unusual Isocoumarin Derivative, 3H-Furo[3,4-c]isochromene-1,5- dione

Title: A Novel Unusual Isocoumarin Derivative, 3H-Furo[3,4-c]isochromene-1,5- dione

Volume: 7 Issue: 7

Author(s): Muhammad Tahir Hussain, Nasim Hasan Rama and Khalid Mohammed Khan

Affiliation:

Keywords: Acetyl chloride, Chloroacetyl chloride, Homophthalic acid, Novel 3H-furo[3,4-c]isochromene-1,5-dione, isocoumarin, spectroscopy, X-ray crystallography, dihydroisocoumarins, naphthalene, NMR, DMF

Abstract: An attempt to prepare 3-substituted isocoumarins by the condensation of acid chlorides with homophthalic acid to afford the desired 3-chloromethylisocoumarin was made but surprisingly the desired isocoumarin (8) was not formed. However, a novel 3H-furo[3,4-c]isochromene-1,5-dione (9) was isolated which was characterized by spectroscopy and Xray crystallography. A mechanism for the formation of 3H-furo[3,4-c]isochromene-1,5-dione (9) is also proposed.

Cite this article as:

Tahir Hussain Muhammad, Hasan Rama Nasim and Mohammed Khan Khalid, A Novel Unusual Isocoumarin Derivative, 3H-Furo[3,4-c]isochromene-1,5- dione, Letters in Organic Chemistry 2010; 7 (7) . https://dx.doi.org/10.2174/157017810793362217