Central Nervous System Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

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Regulatory T Cells in Central Nervous System: in Health and Disease

Author(s): Brenda Saenz, Jesus Perez-H, Anahi Chavarria.

Abstract:

Regulatory T cells participate in several immune responses including autoimmune reactions inducing selftolerance, tumor immunity, transplantation tolerance and microbial infection. Nevertheless, regulatory T cells actions seem to be different when they are in the central nervous system (CNS), since they interact with resident cells of the CNS, according to the particular conditions elicited in this compartment. This review focuses on the role of regulatory T cells in health, autoimmune and other CNS diseases, pointing out their interactions with resident CNS cells.

Keywords: Brain tumor, central nervous system, cerebral vascular diseases, experimental autoimmune encephalomyelitis, multiple sclerosis, neuroinflammation, regulatory T cells, central nervous system (CNS), glucocorticoid-induced TNF receptor (GITR), antigen presenting cells (APC), Tr1 Regulatory Cells, neurodegenerative disorders, antiproliferative action, experimental autoimmune encephalomyelitis (EAE), autoimmune encephalomyelitis, acetylcholine, glutamate, serotonin, vascular disease, microglia activation, brain tumors, glioblastoma multiforme, heme oxygenase-1 (HO-1), neoangiogenesis, cerebral malaria (ECM), Cytotoxic T lymphocyte-associated antigen 4, Glucocorticoid-induced TNF receptor, Major histocompatibility complex class II

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2010
Page: [326 - 336]
Pages: 11
DOI: 10.2174/187152410793429674
Price: $58