Abstract
Thioredoxin reductase plays a critical role in the regulation of cancer cell apoptosis, making it an attractive target for the design of new anticancer drugs. Several classes of compounds have been considered as potential antitumor or chemopreventive agents; most of them apparently interact with thioredoxin reductases C-terminal redox center.
Keywords: Thioredoxin reductase, redox system, antitumour agents, TrxR substrates, alkylating agents, reversible TrxR inhibitor, motexafin gadolinium, ethaselen, Targeting Thioredoxin Reductase, Chemopreventive Compounds, redox homeostasis, 1,2-[bis(1,2-benzisoselenazolone-3, NADPH, TrxR1 mRNA, glutathione reductase, selenenyl-sulfide, FAD domain, Cys mutant enzyme, nucleophilic, platinum compounds, efficaciousness, Motexafin Gadolinium (MGd), Aurothioglucosea, Selenodiglutathione (GS-Se-SG), peroxidase-mimicking, Anticancer Alkylating Agents, aziridinyl quinone diaziquone, Ebselene, cytotoxicity, aurothioglucose, antiproliferative agent, Curcumin, α,β-unsaturated ketone structure, carcinogenesis, mercaptoimidazole moiety, methylseleninate, nasopharyngeal (KB), TrxR inhibition, GSH, ROS
Medicinal Chemistry
Title: Targeting Thioredoxin Reductase: Anticancer Agents and Chemopreventive Compounds
Volume: 6 Issue: 5
Author(s): H. H. Zeng and L. H. Wang
Affiliation:
Keywords: Thioredoxin reductase, redox system, antitumour agents, TrxR substrates, alkylating agents, reversible TrxR inhibitor, motexafin gadolinium, ethaselen, Targeting Thioredoxin Reductase, Chemopreventive Compounds, redox homeostasis, 1,2-[bis(1,2-benzisoselenazolone-3, NADPH, TrxR1 mRNA, glutathione reductase, selenenyl-sulfide, FAD domain, Cys mutant enzyme, nucleophilic, platinum compounds, efficaciousness, Motexafin Gadolinium (MGd), Aurothioglucosea, Selenodiglutathione (GS-Se-SG), peroxidase-mimicking, Anticancer Alkylating Agents, aziridinyl quinone diaziquone, Ebselene, cytotoxicity, aurothioglucose, antiproliferative agent, Curcumin, α,β-unsaturated ketone structure, carcinogenesis, mercaptoimidazole moiety, methylseleninate, nasopharyngeal (KB), TrxR inhibition, GSH, ROS
Abstract: Thioredoxin reductase plays a critical role in the regulation of cancer cell apoptosis, making it an attractive target for the design of new anticancer drugs. Several classes of compounds have been considered as potential antitumor or chemopreventive agents; most of them apparently interact with thioredoxin reductases C-terminal redox center.
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Cite this article as:
H. Zeng H. and H. Wang L., Targeting Thioredoxin Reductase: Anticancer Agents and Chemopreventive Compounds, Medicinal Chemistry 2010; 6 (5) . https://dx.doi.org/10.2174/157340610793358864
DOI https://dx.doi.org/10.2174/157340610793358864 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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Carbohydrates in Computational and Medicinal Chemistry
Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
Recent Advances in the Medicinal Chemistry of Cancer
Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more
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