Evaluation of Substituted Benzaldehydes Against Mycobacterium tuberculosis
Marcelle de Lima Ferreira,
Andre Luis Peixoto Candea,
Maria das Gracas Muller de Oliveira Henriques,
Maria Cristina Silva Lourenco,
Carlos Roland Kaiser,
Marcus Vinicius Nora de Souza.
A series of 48 commercial benzaldehydes have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv, using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. Benzaldehydes 39 and 41 exhibited a significant activity at 3.12 μg/mL. Although commercial benzaldehydes have been largely used by many research groups in search of news TB-drugs, they had not been tested previously against Mycobacterium tuberculosis. This study adds important information to the rational design of new lead anti-TB drugs.
Keywords: Antimycobacterial evaluation, Alamar Blue assay, Benzaldehydes, Cytotoxicity, Drugs, Tuberculosis, Mycobacterium tuberculosis, multidrug-resistant tuberculosis, MDR-TB, drug-resistant tuberculosis, XDR-TB, Rifampin, Isoniazid, Cell Viability Assay, RPMI 1640, DMSO, MABA, BACTEC, SAR, Mosmans's MTT
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