Current Rheumatology Reviews

Dr. Serena Guiducci  
Department of Biomedicine, Division of Rheumatology
University of Florence
Florence
Italy

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Promising Anti-Fibrotic Approaches for Future Treatment of Systemic Sclerosis

Author(s): Jorg H.W. Distler, Oliver Distler.

Abstract:

In the last years, several key-pathways for the aberrant activation of fibroblasts in SSc have been identified in pre-clinical studies. This review summarizes recently identified molecular targets for novel anti-fibrotic approaches in systemic sclerosis (SSc) and other fibrotic disorders. We will focus on pathways that can be targeted by drugs that are either already approved for other indications or that are currently evaluated in clinical trials.

Keywords: Fibrosis, scleroderma, molecular-targeted therapies, Anti-Fibrotic Approaches, Systemic Sclerosis, 5-hydroxy-trypthamine, pro-fibrotic effects, tight-skin 1 (tsk-1), HISTONE DEACETYLASE INHIBITORS, Hyperacetylation, HDACs, anti-fibrotic effects, transcriptional coactivators, multiple malignancies, neoplastic diseases, leukaemia, procainamide, hydralazine, cardiac arrhythmias, RE-CEPTOR γ AGONISTS, PPARγ agonists, Sonic Hedgehog (Shh)

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Article Details

VOLUME: 6
ISSUE: 4
Year: 2010
Page: [305 - 308]
Pages: 4
DOI: 10.2174/157339710793205666
Price: $58