A Facile and Efficient Approach to the Synthesis of Novel Chiral Molecular Tweezers Based on Deoxycholic Acid under Microwave Irradiation

Author(s): Yu Chen , Zhi-Gang Zhao , Xing-Li Liu , Zhi-Chuan Shi .

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 3 , 2011

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Abstract:

A rapid, safe and efficient method for the synthesis of novel molecular tweezers with one chiral arm based on deoxycholic acid was reported. Ten new molecular tweezers have been synthesized in good yields. The structures of these new molecular tweezers were characterized by 1H NMR, IR, MS spectra and elemental analysis. These chiral molecular tweezers showed good enantioselectivity for D-amino acid methyl esters.

Keywords: Molecular tweezer, deoxycholic acid, synthesis, microwave irradiation, molecular recognition

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2011
Page: [210 - 215]
Pages: 6
DOI: 10.2174/157017811795038421
Price: $58