DNA Methylation Biomarkers in Serum for Gastric Cancer Screening

Author(s): Ting Ye, Yingxuan Chen, Jingyuan Fang.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 11 , 2010

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Abstract:

Epigenetic alterations occur throughout the development and carcinogenesis of gastric cancer. Therefore, the detection of methylated DNA markers is predicted to be able to detect gastric cancer earlier, and improve the risk assessment, surveillance, relapse, and prognosis of patients with gastric cancer. Detection of free methylated DNA also represents a promising approach for developing serum-based detection methods for the non-invasive monitoring of gastric cancer progression.

Keywords: DNA methylation, biomarker, serum, gastric cancer, proto-oncogene, tumor suppressor gene, Relapse, Serum-based detection, Non-invasive monitoring, Transcriptional regulation, Proto-oncogenes, Cell cycle regulator genes, Gastric carcinogenesis, Neuroblastoma, Colorectal cancers, Epigenetic alterations, DAP-kinase, Survival prediction

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Article Details

VOLUME: 10
ISSUE: 11
Year: 2010
Page: [1034 - 1038]
Pages: 5
DOI: 10.2174/1389557511009011034
Price: $58

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