A Tribute to Octavio Antunes: A Brazilian Approach to Protease Inhibitors
Jose C. Barros,
Rodrigo Octavio M.A. de Souza,
Joaquim F.M. da Silva,
Eloan dos S. Pinheiro,
The development and synthesis of Protease Inhibitors in a Brazilian group led by Professor O. A. C. Antunes is reviewed focusing on the strategies, molecular modeling studies, synthesis and pharmacological evaluation.
Keywords: HIV, AIDS, Protease, HCV, Octavio Antunes, Protease Inhibitors, Anti-HIV compounds, Tartaravir Derivatives, Catalysis, Unsymmetrical inhibitors, Isomannide Derivatives, D-mannitol, HCV PR, D or L-tartaric acid, Isomannide, Antiretroviral, Nanobiotechnology, Drug Design and Discovery
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