Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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A Tribute to Octavio Antunes: A Brazilian Approach to Protease Inhibitors

Author(s): Jose C. Barros, Rodrigo Octavio M.A. de Souza, Joaquim F.M. da Silva, Eloan dos S. Pinheiro, Amilcar Tanuri.

Abstract:

The development and synthesis of Protease Inhibitors in a Brazilian group led by Professor O. A. C. Antunes is reviewed focusing on the strategies, molecular modeling studies, synthesis and pharmacological evaluation.

Keywords: HIV, AIDS, Protease, HCV, Octavio Antunes, Protease Inhibitors, Anti-HIV compounds, Tartaravir Derivatives, Catalysis, Unsymmetrical inhibitors, Isomannide Derivatives, D-mannitol, HCV PR, D or L-tartaric acid, Isomannide, Antiretroviral, Nanobiotechnology, Drug Design and Discovery

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Article Details

VOLUME: 7
ISSUE: 9
Year: 2010
Page: [707 - 709]
Pages: 3
DOI: 10.2174/157018010792929568
Price: $58