A Tribute to Octavio Antunes: A Brazilian Approach to Protease Inhibitors

Jose      C. Barros; Rodrigo      Octavio M.A. de Souza; Joaquim      F.M. da Silva; Eloan      dos S. Pinheiro; Amilcar      Tanuri

Abstract

The development and synthesis of Protease Inhibitors in a Brazilian group led by Professor O. A. C. Antunes is reviewed focusing on the strategies, molecular modeling studies, synthesis and pharmacological evaluation.

Keywords: HIV, AIDS, Protease, HCV, Octavio Antunes, Protease Inhibitors, Anti-HIV compounds, Tartaravir Derivatives, Catalysis, Unsymmetrical inhibitors, Isomannide Derivatives, D-mannitol, HCV PR, D or L-tartaric acid, Isomannide, Antiretroviral, Nanobiotechnology, Drug Design and Discovery

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Letters in Drug Design & Discovery

Title: A Tribute to Octavio Antunes: A Brazilian Approach to Protease Inhibitors

Volume: 7 Issue: 9

Author(s): Jose C. Barros, Rodrigo Octavio M.A. de Souza, Joaquim F.M. da Silva, Eloan dos S. Pinheiro and Amilcar Tanuri

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Abstract: The development and synthesis of Protease Inhibitors in a Brazilian group led by Professor O. A. C. Antunes is reviewed focusing on the strategies, molecular modeling studies, synthesis and pharmacological evaluation.

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C. Barros Jose, Octavio M.A. de Souza Rodrigo, F.M. da Silva Joaquim, dos S. Pinheiro Eloan and Tanuri Amilcar, A Tribute to Octavio Antunes: A Brazilian Approach to Protease Inhibitors, Letters in Drug Design & Discovery 2010; 7 (9) . https://dx.doi.org/10.2174/157018010792929568