Inflammation & Allergy-Drug Targets (Discontinued)

(Formerly Current Drug Targets - Inflammation & Allergy)

Kurt S Zaenker
Institute of Immunology and Experimental Oncology
University Witten/Herdecke
Stockumerstraße 10
Witten, 58448
Germany

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The Role of Nuclear Factor-κB in Inflammatory Lung Disease

Author(s): Abbas Ali Imanifooladi, Samaneh Yazdani and Mohammad Reza Nourani

Affiliation: Chemical Injury Research Center, Baqiyatallah Medical Sciences University, Tehran, Iran.

Abstract:

Nuclear factor-κB (NF-κB) is one of the most important transcription factors; it has a key role in inflammatory and immune responses, cell adhesion, developmental signals, and anti-apoptosis process. Inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are major causes of morbidity and mortality worldwide. In this review, we highlight the role of NF-κB in inflammatory lung disease, the strategies which block the activation of NF- κB, and the therapeutic approaches to treating inflammatory lung disease.

Keywords: Asthma, cell adhesion, COPD, inflammatory lung disease, NF-κB, therapeutic approach

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Article Details

VOLUME: 9
ISSUE: 3
Page: [197 - 205]
Pages: 9
DOI: 10.2174/187152810792231904
Price: $58