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Inflammation & Allergy-Drug Targets
(Formerly Current Drug Targets - Inflammation & Allergy)
ISSN (Print): 1871-5281
ISSN (Online): 2212-4055
VOLUME: 9
ISSUE: 3
DOI: 10.2174/187152810792231904      Price:  $58









The Role of Nuclear Factor-κB in Inflammatory Lung Disease

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Author(s): Abbas Ali Imanifooladi, Samaneh Yazdani and Mohammad Reza Nourani
Pages 197-205 (9)
Abstract:
Nuclear factor-κB (NF-κB) is one of the most important transcription factors; it has a key role in inflammatory and immune responses, cell adhesion, developmental signals, and anti-apoptosis process. Inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are major causes of morbidity and mortality worldwide. In this review, we highlight the role of NF-κB in inflammatory lung disease, the strategies which block the activation of NF- κB, and the therapeutic approaches to treating inflammatory lung disease.
Keywords:
Asthma, cell adhesion, COPD, inflammatory lung disease, NF-κB, therapeutic approach
Affiliation:
Chemical Injury Research Center, Baqiyatallah Medical Sciences University, Tehran, Iran.