Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives

Author(s): Samir A. Carvalho, Edson F. da Silva, Maria C.S. Lourenco, Marcus V.N. de Souza, Carlos A.M. Fraga.


In this work we report the tuberculostatic profile of a series of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone derivatives (1a-m). The evaluation of their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv was expressed as the minimum inhibitory concentration (MIC) in μg/mL. The compounds 1g and 1h exhibited inhibitory activity of 6.25 μg/mL and 1.25 μg/mL respectively, and can be considered as a good start point for the discovery of new lead compounds in the field of multi-drug resistant tuberculosis.

Keywords: 1,3,4-thiadiazoles, Antimycobacterial activity, N-arylhydrazones, Tuberculosis

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Article Details

Year: 2010
Page: [606 - 609]
Pages: 4
DOI: 10.2174/157018010792062768
Price: $58