Synthesis and Antitumor Evaluation of (E)-2-Benzothiazole Hydrazones
Antonio Francisco Nogueira,
Elisa Carvalho Azevedo,
Vitor Francisco Ferreira,
Ana Jersia Araujo,
Evelyne Alves dos Santos,
Leticia Veras Costa-Lotufo,
Raquel Carvalho Montenegro,
Manoel Odorico de Moraes,
Thatyana Rocha Alves Vasconcelos.
A series of eleven (E)-2-benzothiazole hydrazones were synthesized and evaluated for their in vitro anticancer activities against three neoplastic cancer cells: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). Two of them, 3e and 3f, showed good cytotoxicity activity for HL-60. The results also demonstrated that compound 3f seems to be selective to HL-60 cell line, appearing as a good prototype for an antileukemia lead molecule.
Keywords: Benzothiazoles, Hydrazones, Cancer, Cytotoxicity
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