Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Antitumor Evaluation of (E)-2-Benzothiazole Hydrazones

Author(s): Antonio Francisco Nogueira, Elisa Carvalho Azevedo, Vitor Francisco Ferreira, Ana Jersia Araujo, Evelyne Alves dos Santos, Claudia Pessoa, Leticia Veras Costa-Lotufo, Raquel Carvalho Montenegro, Manoel Odorico de Moraes, Thatyana Rocha Alves Vasconcelos.

Abstract:

A series of eleven (E)-2-benzothiazole hydrazones were synthesized and evaluated for their in vitro anticancer activities against three neoplastic cancer cells: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). Two of them, 3e and 3f, showed good cytotoxicity activity for HL-60. The results also demonstrated that compound 3f seems to be selective to HL-60 cell line, appearing as a good prototype for an antileukemia lead molecule.

Keywords: Benzothiazoles, Hydrazones, Cancer, Cytotoxicity

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Article Details

VOLUME: 7
ISSUE: 8
Year: 2010
Page: [551 - 555]
Pages: 5
DOI: 10.2174/157018010792062740
Price: $58