One-Pot Four-Component Synthesis of 3-(1,3,4-Thiadiazol-2-ylamino)-3-arylpropanoates

Title: One-Pot Four-Component Synthesis of 3-(1,3,4-Thiadiazol-2-ylamino)-3-arylpropanoates

Volume: 7 Issue: 6

Author(s): Zheng Li, Yanbo Li, Hongfang Cai, Jun Xu and Jinghong Shi

Affiliation:

Keywords: β-Amino acid ester, condensation, four-component synthesis, Meldrum's acid, 1,3,4-thiadiazole, 3-(1,3,4-thiadiazol-2-ylamino)-3-arylpropanoate

Abstract: A novel one-pot four-component synthetic method for 3-(1,3,4-thiadiazol-2-ylamino)-3-arylpropanoates by condensation of 2-amino-1,3,4-thiadiazoles, aldehydes, Meldrums acid and aliphatic alcohols catalyzed by p-toluenesulfonic acid was described. The protocol has advantages of mild conditions, high yield and simple work-up procedure.

Cite this article as:

Li Zheng, Li Yanbo, Cai Hongfang, Xu Jun and Shi Jinghong, One-Pot Four-Component Synthesis of 3-(1,3,4-Thiadiazol-2-ylamino)-3-arylpropanoates, Letters in Organic Chemistry 2010; 7 (6) . https://dx.doi.org/10.2174/157017810791824964