A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III
Hui Zhou, Dahai Chen, Hongwei Gao and Qingeng Li
Affiliation: College of Pharmacy, Chongqing Medical University, P. R., 400016, China.
A novel protocol for the semi-synthesis of docetaxel was achieved in four steps from 10-deacetyl baccatin III with an overall yield of 50%. The key step is the selective protection of the C(7) and C(10) hydroxyl groups of 10- deacetyl baccatin III, utilizing benzyl chloromate as a selective protecting reagent, which are capable of being conveniently removed by Pd/C under hydrogen atmosphere.
Keywords: Docetaxel, semi-synthesis, 10-DAB III, benzyl chloromate
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