Letters in Organic Chemistry

Miguel Yus  
Universidad de Alicante Apdo
Alicante
Spain

Back

A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III

Author(s): Hui Zhou, Dahai Chen, Hongwei Gao and Qingeng Li

Affiliation: College of Pharmacy, Chongqing Medical University, P. R., 400016, China.

Abstract:

A novel protocol for the semi-synthesis of docetaxel was achieved in four steps from 10-deacetyl baccatin III with an overall yield of 50%. The key step is the selective protection of the C(7) and C(10) hydroxyl groups of 10- deacetyl baccatin III, utilizing benzyl chloromate as a selective protecting reagent, which are capable of being conveniently removed by Pd/C under hydrogen atmosphere.

Keywords: Docetaxel, semi-synthesis, 10-DAB III, benzyl chloromate

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 7
ISSUE: 6
Page: [450 - 452]
Pages: 3
DOI: 10.2174/157017810791824892
Price: $58