Current Protein & Peptide Science

Ben M. Dunn  
Department of Biochemistry and Molecular Biology University of Florida
College of Medicine, P.O. Box 100245, Gainesville
Florida, FL 32610-0245
USA

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A Summary of Computational Resources for Protein Phosphorylation

Author(s): Yu Xue, Xinjiao Gao, Jun Cao, Zexian Liu, Changjiang Jin, Longping Wen, Xuebiao Yao, Jian Ren.

Abstract:

Protein phosphorylation is the most ubiquitous post-translational modification (PTM), and plays important roles in most of biological processes. Identification of site-specific phosphorylated substrates is fundamental for understanding the molecular mechanisms of phosphorylation. Besides experimental approaches, prediction of potential candidates with computational methods has also attracted great attention for its convenience, fast-speed and low-cost. In this review, we present a comprehensive but brief summarization of computational resources of protein phosphorylation, including phosphorylation databases, prediction of non-specific or organism-specific phosphorylation sites, prediction of kinase-specific phosphorylation sites or phospho-binding motifs, and other tools. The latest compendium of computational resources for protein phosphorylation is available at: http://gps.biocuckoo.org/links.php

Keywords: Phosphorylation, post-translational modification, kinase-specific, phospho-binding motif, phosphorylation network

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Article Details

VOLUME: 11
ISSUE: 6
Year: 2010
Page: [485 - 496]
Pages: 12
DOI: 10.2174/138920310791824138
Price: $58