Synthesis and Cytotoxic Activities of 2-(4-(2-heterocycloethoxy)phenyl)- 1,2,4-triazolo[1,5-a] Pyridines

Author(s): Guolin Zhang , Jun Chen .

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 3 , 2011

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Abstract:

Nine 2-(4-(2-heterocycloethoxy)phenyl)-1,2,4-triazolo[1,5-a] pyridines have been synthesized. The structures of all products were confirmed by 1H NMR and HRMS. The cytotoxic activities of these compounds were evaluated against human ovary cancer cell line (HO-8910) in vitro by MTT method. The preliminary results showed that compound 4e (IC50 0.11mM) and compound 4f (IC50 0.11mM) exhibited moderate activity against the cancer cell line when compared with Cisplatin.

Keywords: Synthesis, cytotoxic, 1,2,4-triazolo[1,5-a] pyridines, benzyloxyphenyl, methyl, fungi, cycloethoxy, phenyl, ethyloxyphenyl, morpholino

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2011
Page: [180 - 183]
Pages: 4
DOI: 10.2174/157017811795038377
Price: $58

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