Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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Leukemia Stem Cells and New Strategies to Overcome Resistance to Therapy

Author(s): Xavier Thomas, Giovanna Cannas.

Abstract:

Acute leukemias are the result of aberrant hematopoietic processes initiated by rare leukemia stem cells that have maintained or acquired the capacity of indefinite proliferation through accumulated mutations and/or epigenetic changes. The most likely view of hematopoietic cell lineage organization is that of complex reactive or adaptative systems. The properties of leukemia stem cells indicate that current chemotherapy will not be effective. Furthermore, recent advances indicate that stem cell microenvironment directly affects cell fate decisions. Because they are quiescent, leukemia stem cells do not respond to cell cycle-specific cytotoxic agents used in treating leukemia, which contribute to treatment failure. New strategies are required that specifically target the malignant stem cell population.

Keywords: Acute myeloid leukemia, emerging drugs, leukemia stem cells, resistance

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2010
Page: [277 - 286]
Pages: 10
DOI: 10.2174/157488810791824485
Price: $58