Abstract
Cancer, a leading cause of death, can be prevented by different nutrients, in accordance to epidemiological and experimental data. Cancer chemoprevention might involve different dietary substances, which can counteract genetic damage and modulate the acquisition of a neoplastic phenotype. Critical to this process is redox cellular homeostasis, with antioxidants and essential biomolecules being the most promising functional compounds of the diet. Nutritional interventions require accurate biomarkers in order to evaluate their appropriateness. Such parameters may be biological targets involved in the oncogenetic process, and biochemical changes deriving from the organic response to tumours, which can be considered as endpoints of dietary interventions. This review will thus focus on patents on recent progress in the development of redox-related anticancer nutritional interventions involving lipophilic compounds, and of biological markers for evaluating them, with their scientific basis being reviewed.
Keywords: Apoptosis, biomarker, cancer, chemoprevention, cytotoxicity, diet, fatty acid, flavonoid, free radical, lipid, nutrition, oxidative stress, polyphenol
Recent Patents on Anti-Cancer Drug Discovery
Title: Biomarker Assessment in Nutritional Modulation of Oxidative Stress-Induced Cancer Development by Lipid-Related Bioactive Molecules
Volume: 5 Issue: 3
Author(s): Maria D. Defago and Elio A. Soria
Affiliation:
Keywords: Apoptosis, biomarker, cancer, chemoprevention, cytotoxicity, diet, fatty acid, flavonoid, free radical, lipid, nutrition, oxidative stress, polyphenol
Abstract: Cancer, a leading cause of death, can be prevented by different nutrients, in accordance to epidemiological and experimental data. Cancer chemoprevention might involve different dietary substances, which can counteract genetic damage and modulate the acquisition of a neoplastic phenotype. Critical to this process is redox cellular homeostasis, with antioxidants and essential biomolecules being the most promising functional compounds of the diet. Nutritional interventions require accurate biomarkers in order to evaluate their appropriateness. Such parameters may be biological targets involved in the oncogenetic process, and biochemical changes deriving from the organic response to tumours, which can be considered as endpoints of dietary interventions. This review will thus focus on patents on recent progress in the development of redox-related anticancer nutritional interventions involving lipophilic compounds, and of biological markers for evaluating them, with their scientific basis being reviewed.
Export Options
About this article
Cite this article as:
D. Defago Maria and A. Soria Elio, Biomarker Assessment in Nutritional Modulation of Oxidative Stress-Induced Cancer Development by Lipid-Related Bioactive Molecules, Recent Patents on Anti-Cancer Drug Discovery 2010; 5 (3) . https://dx.doi.org/10.2174/157489210791760481
DOI https://dx.doi.org/10.2174/157489210791760481 |
Print ISSN 1574-8928 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3970 |
Call for Papers in Thematic Issues
Novel anti-cancer drugs in photoimmunotherapy management: from bench to translational research
In recent years, traditional cancer treatments, such as surgery, chemotherapy, and radiation treatment, etc., may damage the pathological tissue and normal cells. The ideal tumor treatment should be noninvasive, eliminating the primary tumor, making the body produce systemic tumor-specific immunity, eliminating metastases, and having less /no side effects. Recent Patents ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Association and Causal Relationship of Midlife Obesity and Related Metabolic Disorders with Old Age Cognition
Current Alzheimer Research Platelet Function and Antiplatelet Therapy in Cardiovascular Disease: Implications of Genetic Polymorphisms
Current Vascular Pharmacology Nucleic Acid Sequence Based Amplification (NASBA) of Chlamydia pneumoniae Major Outer Membrane Protein (ompA) mRNA with Bioluminescent Detection
Combinatorial Chemistry & High Throughput Screening The Antioxidant Activity of Coumarins and Flavonoids
Mini-Reviews in Medicinal Chemistry Metabolic Correction in the Management of Diabetic Peripheral Neuropathy: Improving Clinical Results Beyond Symptom Control
Current Clinical Pharmacology Role of PI3 Kinase Gamma in Excitation-Contraction Coupling and Heart Disease
Cardiovascular & Hematological Disorders-Drug Targets Microparticles: A Pivotal Nexus in Vascular Homeostasis and Disease
Current Clinical Pharmacology Selenium Containing Compounds from Poison to Drug Candidates: A Review on the GPx-like Activity
Current Chemical Biology Haptoglobin Polymorphism and Lacunar Stroke
Current Neurovascular Research Molecular Targets of Diabetic Vascular Complications and Potential New Drugs
Current Drug Targets Bioenergetics and Mitochondrial Dysfunction in Aging: Recent Insights for a Therapeutical Approach
Current Pharmaceutical Design Augmentation of Creatine in the Heart
Mini-Reviews in Medicinal Chemistry Cell Sources in Cardiac Tissue Engineering: Current Choices
Current Stem Cell Research & Therapy Hydrogen Sulfide Regulates Vascular Inflammation and its Related Signaling Pathways
Current Signal Transduction Therapy von Willebrand Factor, von Willebrand Factor-Cleaving Protease, and Shear Stress
Cardiovascular & Hematological Agents in Medicinal Chemistry Cytokine Polymorphisms in Chronic Inflammatory Diseases with Reference to Occupational Diseases
Current Molecular Medicine Treatment of Foot Disease in Patients with Type 2 Diabetes Mellitus using Human Umbilical Cord Blood Mesenchymal Stem Cells: Response and Correction of Immunological Anomalies
Current Pharmaceutical Design The Digenea Parasite Opisthorchis felineus: A Target for the Discovery and Development of Novel Drugs
Infectious Disorders - Drug Targets Animal Models of Atherosclerosis Progression: Current Concepts
Current Drug Targets - Cardiovascular & Hematological Disorders The Cardiovascular Protective Effects of Chrysin: A Narrative Review on Experimental Researches
Cardiovascular & Hematological Agents in Medicinal Chemistry