Cyclodextrins: More than Pharmaceutical Excipients

Author(s): F.J. Otero-Espinar, A. Luzardo-Alvarez, J. Blanco-Mendez.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 8 , 2010

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Abstract:

Cyclodextrins are pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drugs. Recent findings have shown them to display adjuvant activity in vaccine therapy and prophylactic and therapeutic activity in the treatment of several host-pathogen infections. This article focuses on their activity and mechanism of action.

Keywords: Cyclodextrins, protein refolding, Bacillus anthracis, Cryptosporidium spp., Human Immunodeficiency Virus, immunomodulation, Leishmania spp., Plasmodium spp.

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Article Details

VOLUME: 10
ISSUE: 8
Year: 2010
Page: [715 - 725]
Pages: 11
DOI: 10.2174/138955710791572479
Price: $58

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