Mini-Reviews in Medicinal Chemistry


Fullerenes: From Carbon to Nanomedicine

Author(s): Pooja Chawla, Viney Chawla, Radhika Maheshwari, Shubhini A. Saraf and Shailendra K. Saraf

Affiliation: Faculty of Pharmacy, Northern India Engineering College, Dr. Akhilesh Das Nagar, Sector 1, Faizabad road, Chinhut, Lucknow-227105, India.


Fullerenes, the third carbon allotrope, have emerged as agents which could revolutionize the treatment of many diseases. Fullerenes possess different biological applications like neuroprotective agents, antioxidants, anti-HIV activity, enzyme inhibition, antiapoptotic activity and the list is ever increasing. Moreover, they are being utilized as drug carrier systems and also for many non-biological applications like superconductors, catalysis and so on. Their size has made them promising agents for nanotechnology. This article aims at outlining the chemistry, properties and non-biological applications of fullerenes and their evolution to biological applications, thereby traversing their evolution from simple carbon allotropes to present day nano-medicinal agents.

Keywords: Anti HIV, antioxidant, antiapoptotic, enzyme inhibition, nanomedicines, neuroprotective

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Article Details

Page: [662 - 677]
Pages: 16
DOI: 10.2174/138955710791572497