Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis, Characterization by Means of IR, 1H, 13C - NMR and Biological Investigations on New Diorganotin Carboxylic Acid Derivatives

Author(s): Abderrahmane Yahyi, Abdelkader Et-Touhami, Rachid Yahyaoui, Rachid Touzani.

Abstract:

New organotin (IV) based on 2-(thiophene-2-yl)acetic acid and 1-H-pyrazole-3-carboxylic acid derivatives 1-ae and 2a-e was prepared and characterized by IR, 1H and 13C NMR spectroscopy. These reactions were carried out under refluxing conditions using CHCl3 / EtOH (3:1) as solvents and 2:1 / 1:1 acid / metal oxide rations. The tin products were recuperated with moderate and good yields (55-85%). The Compounds (1b, 1e and 2e) were screened for their antitumor activities against two human tumor cell lines: HeLa, an epithelial cell from a fatal cervical carcinoma and HEK293, an embryonic kidney tumor. All three materials show an activity in vitro against these cell lines.

Keywords: Synthesis, Tin, Carboxylic acids, Antitumor activities

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Article Details

VOLUME: 7
ISSUE: 7
Year: 2010
Page: [534 - 540]
Pages: 7
DOI: 10.2174/157018010791526241
Price: $58