Triterpenes from Gloeophyllum odoratum as Potential Leads Towards Potent Thrombin Inhibitors

Title: Triterpenes from Gloeophyllum odoratum as Potential Leads Towards Potent Thrombin Inhibitors

Volume: 7 Issue: 7

Author(s): Francesca Cateni, Vittorio Lucchini, Marko Anderluh, Paolo Martinuzzi, Marina Zacchigna, Andrej Piltaver and Bojan Doljak

Affiliation:

Keywords: Gloeophyllum odoratum, 3α-Hydroxy-12β-acetoxy-lanosta-8,24-dien-29-oic acid, Inhibitor, Thrombin, Triterpenes, Trypsin

Abstract: A bioassay oriented fractionation of Gloeophyllum odoratum dry extract has led to the isolation of three active fractions. On the basis of spectroscopic data, MS spectroscopy and microanalysis a new tetracyclic triterpene: 3α- hydroxy-12β-acetoxy-lanosta-8,24-dien-29-oic acid, together with two known ones: trametenolic acid and 15α- hydroxytrametenolic acid, have been isolated, identified and proved to selectively inhibit thrombin but not trypsin.

Cite this article as:

Cateni Francesca, Lucchini Vittorio, Anderluh Marko, Martinuzzi Paolo, Zacchigna Marina, Piltaver Andrej and Doljak Bojan, Triterpenes from Gloeophyllum odoratum as Potential Leads Towards Potent Thrombin Inhibitors, Letters in Drug Design & Discovery 2010; 7 (7) . https://dx.doi.org/10.2174/157018010791526340