Triterpenes from Gloeophyllum odoratum as Potential Leads Towards Potent Thrombin Inhibitors
A bioassay oriented fractionation of Gloeophyllum odoratum dry extract has led to the isolation of three active fractions. On the basis of spectroscopic data, MS spectroscopy and microanalysis a new tetracyclic triterpene: 3α- hydroxy-12β-acetoxy-lanosta-8,24-dien-29-oic acid, together with two known ones: trametenolic acid and 15α- hydroxytrametenolic acid, have been isolated, identified and proved to selectively inhibit thrombin but not trypsin.
Keywords: Gloeophyllum odoratum, 3α-Hydroxy-12β-acetoxy-lanosta-8,24-dien-29-oic acid, Inhibitor, Thrombin, Triterpenes, Trypsin
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