Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Triterpenes from Gloeophyllum odoratum as Potential Leads Towards Potent Thrombin Inhibitors

Author(s): Francesca Cateni, Vittorio Lucchini, Marko Anderluh, Paolo Martinuzzi, Marina Zacchigna, Andrej Piltaver, Bojan Doljak.

Abstract:

A bioassay oriented fractionation of Gloeophyllum odoratum dry extract has led to the isolation of three active fractions. On the basis of spectroscopic data, MS spectroscopy and microanalysis a new tetracyclic triterpene: 3α- hydroxy-12β-acetoxy-lanosta-8,24-dien-29-oic acid, together with two known ones: trametenolic acid and 15α- hydroxytrametenolic acid, have been isolated, identified and proved to selectively inhibit thrombin but not trypsin.

Keywords: Gloeophyllum odoratum, 3α-Hydroxy-12β-acetoxy-lanosta-8,24-dien-29-oic acid, Inhibitor, Thrombin, Triterpenes, Trypsin

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Article Details

VOLUME: 7
ISSUE: 7
Year: 2010
Page: [521 - 527]
Pages: 7
DOI: 10.2174/157018010791526340
Price: $58