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Protein & Peptide Letters
ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
VOLUME: 17
ISSUE: 8
DOI: 10.2174/092986610791498858      Price:  $58









Crystal Structure of the Apo Form of D-Alanine:D-Alanine Ligase (DDl) from Streptococcus mutans

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Author(s): Yongzhi Lu, Hongyan Xu and Xiaojun Zhao
Pages 1053-1057 (5)
Abstract:
D-Alanine:D-Alanine ligase (DDl) catalyzes the formation of D-Alanine:D-Alanine dipeptide and is an essential enzyme in bacterial cell wall biosynthesis. This enzyme does not have a human ortholog, making it an attractive target for developing new antibiotic drugs. We determined the crystal structure at 2.23 Å resolution of DDl from Streptococcus mutans (SmDDl), the principal aetiological agent of human dental caries. This structure reveals that SmDDl is a dimer and has a disordered ω-loop region.
Keywords:
X-ray crystal structure, amino acids and peptides, DDl, Streptococcus mutans
Affiliation:
Nanomedicine Laboratory, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.