Multicomponent Reactions Stereo- and Regioselective Three-Component Reaction in Water: Synthesis of Triazole Substituted β-Lactams Via Click Chemistry

Author(s): Ming Lei , Wang-Ze Song , Zu-Jin Zhan , Sun-Liang Cui , Fang-Rui Zhong .

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 3 , 2011

Become EABM
Become Reviewer

Abstract:

Three-component reaction in water was used to prepare a series of triazole substituted trans-β-lactams from the corresponding trans-4-acetoxy-lactam, sodium azide, and alkynes via a Cu(I)-catalyzed click chemistry with base free. This highly stereo- and regioselective procedure is simple, clean and efficient.

Keywords: Three-component reaction, β-lactam, 3R,4R-4-acetoxy-3-[(R)-1-((tert-butyldimethyl-silyl)oxy)-ethyl]-2-azetidinone, click reaction, triazole, stereo- and regioselective reaction, monobactams, carbacephems, carbapenems, sulfinylazetidin

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 8
ISSUE: 3
Year: 2011
Page: [163 - 169]
Pages: 7
DOI: 10.2174/157017811795038430
Price: $58

Article Metrics

PDF: 2