Abstract
Natural products are an abundant source of anti cancer agents. They act as cytotoxic drugs, and inhibitors of apoptosis, transcription, cell proliferation and angiogenesis. While pathways targeted by natural products have been well studied, there is paucity of information about the in vivo molecular target/s of these compounds. This review summarizes some of the natural compounds for which the molecular targets, mechanism of action and structural basis of specificity have been well documented. These examples illustrate that off target binding can be explained on the basis of diversity inherent to biomolecular interactions. There is enough evidence to suggest that natural compounds are potent and versatile warheads that can be optimized for a multi targeted therapeutic intervention in cancer.
Keywords: Natural products, molecular target, specificity, mechanism, structure, cancer
Mini-Reviews in Medicinal Chemistry
Title: Specificity in the Interaction of Natural Products with their Target Proteins- A Biochemical and Structural Insight
Volume: 10 Issue: 6
Author(s): P. Venkatraman
Affiliation:
Keywords: Natural products, molecular target, specificity, mechanism, structure, cancer
Abstract: Natural products are an abundant source of anti cancer agents. They act as cytotoxic drugs, and inhibitors of apoptosis, transcription, cell proliferation and angiogenesis. While pathways targeted by natural products have been well studied, there is paucity of information about the in vivo molecular target/s of these compounds. This review summarizes some of the natural compounds for which the molecular targets, mechanism of action and structural basis of specificity have been well documented. These examples illustrate that off target binding can be explained on the basis of diversity inherent to biomolecular interactions. There is enough evidence to suggest that natural compounds are potent and versatile warheads that can be optimized for a multi targeted therapeutic intervention in cancer.
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Cite this article as:
Venkatraman P., Specificity in the Interaction of Natural Products with their Target Proteins- A Biochemical and Structural Insight, Mini-Reviews in Medicinal Chemistry 2010; 10 (6) . https://dx.doi.org/10.2174/138955710791384090
DOI https://dx.doi.org/10.2174/138955710791384090 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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