Abstract
Progesterone is a major female steroid hormone produced by the ovarian corpus luteum and by the placental syncyiotrophoblast during the second trimester. The biological effects of this steroid hormone are mediated by the ubiquitously expressed progesterone receptor. The exact link between progesterone and female reproductive organ cancer is a controversial issue with various cross-talks. The present review summarizes recent trends in the development of some (anti)progestagen in the cure and management of breast and uterine cancers.
Keywords: Progesterone receptor, progestagens, agonists, antagonists, anti-cancer
Mini-Reviews in Medicinal Chemistry
Title: Progesterone Receptor Agonists and Antagonists as Anticancer Agents
Volume: 10 Issue: 6
Author(s): A. Chakraborty, S. Chatterjee and P. Roy
Affiliation:
Keywords: Progesterone receptor, progestagens, agonists, antagonists, anti-cancer
Abstract: Progesterone is a major female steroid hormone produced by the ovarian corpus luteum and by the placental syncyiotrophoblast during the second trimester. The biological effects of this steroid hormone are mediated by the ubiquitously expressed progesterone receptor. The exact link between progesterone and female reproductive organ cancer is a controversial issue with various cross-talks. The present review summarizes recent trends in the development of some (anti)progestagen in the cure and management of breast and uterine cancers.
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Cite this article as:
Chakraborty A., Chatterjee S. and Roy P., Progesterone Receptor Agonists and Antagonists as Anticancer Agents, Mini-Reviews in Medicinal Chemistry 2010; 10 (6) . https://dx.doi.org/10.2174/138955710791384108
DOI https://dx.doi.org/10.2174/138955710791384108 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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