Interstitial Lung Disease in Rheumatoid Arthritis
Kevin R. Flaherty,
Eric L. Matteson,
Kevin K. Brown,
Paul F. Dellaripa.
Rheumatoid arthritis (RA) affects 1-2% of the general population. Although often thought of as primarily a localized inflammatory disorder with associated joint destruction, it is a diffuse systemic disease. Extra-articular manifestations of rheumatoid arthritis can be demonstrated in almost 50% of patients with RA, and include pulmonary, cardiac, ocular, renal, hematologic, and neurologic involvement. In this article, we review recent studies of interstitial lung disease (ILD) in RA with a focus on clinical and pathological features of rheumatoid arthritis associated interstitial lung disease (RA-ILD). We discuss an approach to the diagnosis and treatment of RA-ILD including potential biomarkers, and conclude by outlining areas for future research.
Keywords: Rheumatoid arthritis, interstitial lung disease, pulmonary fibrosis
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