Abstract
A new series of 7-fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones was synthesized as potential antitumor agents by multi-step synthesis starting with the commercially available 3-chloro-4-fluoroaniline. The most promising candidate, 7-fluoro-6-(4- methyl-1-thyl-1-piperazinyl)- 2-thioethyl-4(3H)-quinazolinone (5a), was screened in 60 human cancer cells by NCI.
Keywords: Quinazolinone derivatives, piperazine derivatives, anticancer activity
Letters in Organic Chemistry
Title: Synthesis and In-Vitro Antitumor Activity of Selected 7-Fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones
Volume: 7 Issue: 5
Author(s): Raid J. Abdel-Jalil, Ehab Al-Momani, Lubna Tahtamooni, H.-Juergen Machulla and Wolfgang Voelter
Affiliation:
Keywords: Quinazolinone derivatives, piperazine derivatives, anticancer activity
Abstract: A new series of 7-fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones was synthesized as potential antitumor agents by multi-step synthesis starting with the commercially available 3-chloro-4-fluoroaniline. The most promising candidate, 7-fluoro-6-(4- methyl-1-thyl-1-piperazinyl)- 2-thioethyl-4(3H)-quinazolinone (5a), was screened in 60 human cancer cells by NCI.
Export Options
About this article
Cite this article as:
J. Abdel-Jalil Raid, Al-Momani Ehab, Tahtamooni Lubna, Machulla H.-Juergen and Voelter Wolfgang, Synthesis and In-Vitro Antitumor Activity of Selected 7-Fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones, Letters in Organic Chemistry 2010; 7 (5) . https://dx.doi.org/10.2174/157017810791514751
DOI https://dx.doi.org/10.2174/157017810791514751 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Transcriptional Regulation of Antimicrobial Host Defense Peptides
Current Protein & Peptide Science The Structural Features of α-Conotoxin Specifically Target Different Isoforms of Nicotinic Acetylcholine Receptors
Current Topics in Medicinal Chemistry Protease Inhibitors in the Clinic
Medicinal Chemistry Estrogen Regulation of MicroRNA Expression
Current Genomics Imaging Drug Resistance with Radiolabeled Molecules
Current Pharmaceutical Design Meet the Editorial Board:
Current Cancer Drug Targets Inhibition of RET Activated Pathways: Novel Strategies for Therapeutic Intervention in Human Cancers
Current Pharmaceutical Design Targeting Tumor Proteasome with Traditional Chinese Medicine
Current Drug Discovery Technologies Peptidyl Prolyl Isomerase, Pin1 is a Potential Target for Enhancing the Therapeutic Efficacy of Etoposide
Current Cancer Drug Targets Multimodality Imaging of CXCR4 in Cancer: Current Status towards Clinical Translation
Current Molecular Medicine A Review of Mechanisms of Circumvention and Modulation of Chemotherapeutic Drug Resistance
Current Cancer Drug Targets Angiogenesis in Chronic Lymphocytic Leukemia
Current Angiogenesis (Discontinued) Mitochondria-Targeting Anticancer Metal Complexes
Current Medicinal Chemistry Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials
Current Drug Metabolism Association Between Chlamydia pneumoniae Antibodies and Lung Cancer: A Meta-Analysis
Current Respiratory Medicine Reviews Biological Activity of Carotenoids: Its Implications in Cancer Risk and Prevention
Current Pharmaceutical Biotechnology Prodrugs of Non-steroidal Anti-inflammatory Drugs (NSAIDs): A Long March Towards Synthesis of Safer NSAIDs
Mini-Reviews in Medicinal Chemistry Obesity Modulation - The Role in Carcinogenesis
Anti-Cancer Agents in Medicinal Chemistry Therapeutic Immunoconjugates. Which Cytotoxic Payload: Chemotherapeutic Drug (ADC) or Radionuclide (ARC) ?
Current Cancer Therapy Reviews miRNA and Proteomic Dysregulation in Non-Small Cell Lung Cancer in Response to Cigarette Smoke
MicroRNA