The Two Pathways for Effective Orthogonal Protection of L-Ornithine, for Amino Acylation of 5-O-Pivaloyl Nucleosides, Describe the General and Important Role for the Successful Imitation, During the Synthesis of the Model Substrates for the Ribosomal Mimic Reaction

Author(s): Stanislav G. Bayryamov, Nikolay G. Vassilev, Dimiter D. Petkov.

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 7 , 2010

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Abstract:

Bz(NO2)-Orn(Boc)-OCH2CN was synthesized as an amino acid component with effective and successful orthogonal protection for amino acylation of 5-O-Pivaloyl nucleosides and preparation of substrates for model ribosome reactions. The synthesis was carried out using suitable combinations of the methods of peptide synthesis and modification of amino acids.

Keywords: Conventional peptide synthesis, orthogonal protection, ornithine

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Article Details

VOLUME: 17
ISSUE: 7
Year: 2010
Page: [889 - 898]
Pages: 10
DOI: 10.2174/092986610791306625
Price: $65

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