Design, Synthesis and Preliminary Activity Evaluation of Novel L-Lysine Derivatives as Aminopeptidase N/CD13 Inhibitors

Author(s): Qiang Wang, Fuming Xu, Jiajia Mou, Jian Zhang, Luqing Shang, Yepeng Luan, Yumei Yuan, Yingzi Liu, Minyong Li, Hao Fang, Binghe Wang, Wenfang Xu.

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 7 , 2010

Become EABM
Become Reviewer

Abstract:

A novel class of L-lysine derivatives as aminopeptidase N (APN) inhibitors was designed and synthesized. Activity evaluation showed that compound C7 (IC50 = 9.6 ± 1.3 μM) and C20 (IC50 = 13.6 ± 1.9 μM) were equivalent to the positive control Bestatin (IC50 = 11.3 ± 1.6 μM).

Keywords: Lysine derivatives, Synthesis, APN, Inhibitor

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 17
ISSUE: 7
Year: 2010
Page: [847 - 853]
Pages: 7
DOI: 10.2174/092986610791306661
Price: $65

Article Metrics

PDF: 10