Design, Synthesis and Preliminary Activity Evaluation of Novel L-Lysine Derivatives as Aminopeptidase N/CD13 Inhibitors

Title: Design, Synthesis and Preliminary Activity Evaluation of Novel L-Lysine Derivatives as Aminopeptidase N/CD13 Inhibitors

Volume: 17 Issue: 7

Author(s): Qiang Wang, Fuming Xu, Jiajia Mou, Jian Zhang, Luqing Shang, Yepeng Luan, Yumei Yuan, Yingzi Liu, Minyong Li, Hao Fang, Binghe Wang and Wenfang Xu

Affiliation:

Keywords: Lysine derivatives, Synthesis, APN, Inhibitor

Abstract: A novel class of L-lysine derivatives as aminopeptidase N (APN) inhibitors was designed and synthesized. Activity evaluation showed that compound C7 (IC50 = 9.6 ± 1.3 μM) and C20 (IC50 = 13.6 ± 1.9 μM) were equivalent to the positive control Bestatin (IC50 = 11.3 ± 1.6 μM).

Cite this article as:

Wang Qiang, Xu Fuming, Mou Jiajia, Zhang Jian, Shang Luqing, Luan Yepeng, Yuan Yumei, Liu Yingzi, Li Minyong, Fang Hao, Wang Binghe and Xu Wenfang, Design, Synthesis and Preliminary Activity Evaluation of Novel L-Lysine Derivatives as Aminopeptidase N/CD13 Inhibitors, Protein & Peptide Letters 2010; 17 (7) . https://dx.doi.org/10.2174/092986610791306661