Acafusin, a Dimeric Antifungal Protein from Acacia confusa Seeds

Author(s): Sze Kwan Lam, Tzi Bun Ng.

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 7 , 2010

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Abstract:

A dimeric 34-kDa antifungal protein, designated as acafusin, was purified from Acacia confusa seeds using Q-Sepharose, DEAE-cellulose, Mono S and Superdex S75. It demonstrated antifungal activity toward Rhizoctonia solani with an IC50 of 28 μM. Acafusin inhibited the activity of HIV-1 reverse transcriptase mildly with an IC50 of 80 μM.

Keywords: Acacia confusa, antifungal protein, HIV-1 reverse transcriptase inhibitory

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Article Details

VOLUME: 17
ISSUE: 7
Year: 2010
Page: [817 - 822]
Pages: 6
DOI: 10.2174/092986610791306643
Price: $65

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