Current Protein & Peptide Science

Ben M. Dunn  
Department of Biochemistry and Molecular Biology University of Florida
College of Medicine, P.O. Box 100245, Gainesville
Florida, FL 32610-0245
USA

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Lipid Membranes and β-Amyloid: A Harmful Connection

Author(s): G.P. Eckert, W.G. Wood and W.E. Muller

Affiliation: Goethe-University of Frankfurt, Department of Pharmacology, Campus Riedberg, Biocenter N260 R1.09, Max-von-Laue Strabe 9, D-60438 Frankfurt, Germany.

Abstract:

Gradual changes in steady-state levels of beta amyloid peptides (Aβ) in the brain are considered as initial step in the amyloid cascade hypothesis of Alzheimers disease (AD). Aβ is a product of the secretase cleavage of the amyloid precursor protein and there is evidence that the membrane lipid environment may modulate secretase activity and alters its function. Aβ disturbs membrane properties of artificial and isolated biological membranes and of plasma membranes in living cells. Aβ induced changes in membrane fluidity could be explained by physico-chemical interactions of the peptide with membrane components such as cholesterol, phospholipids and gangliosides. Thus, cell membranes may be the location where the neurotoxic cascade of Aβ is initiated. Perturbation of membranes, binding to lipids and alteration of cellular calcium signaling by Aβ have been reported by several studies and these topics are examined in this review.

Keywords: Amyloid, membrane, membrane fluidity, cholesterol, ganglioside, Alzheimer, calcium, pyrene, diphenylhexatriene

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Article Details

VOLUME: 11
ISSUE: 5
Page: [319 - 325]
Pages: 7
DOI: 10.2174/138920310791330668
Price: $58