Synthesis and Anticoccidial Activity of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) Quinazolinone Derivatives

Yuanyuan      Zhang; Guangmin      Chen; Yabiao      Weng; Renliang      Li; Yuliang      Wang; Yuzhong      Wang

Abstract

A series of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone derivatives (8a-k) were designed and synthesized. Their anticoccidial activities were evaluated against Eimeria tenella in vivo. The results indicated that compounds 8a, 8b and 8e exhibited anticoccidial activity against Eimeria tenella in the chickens diet with a dose of 18 mg/Kg.

Keywords: 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone, Derivatives, Synthesis, Anticoccidial activity, Eimeria tenella

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Letters in Drug Design & Discovery

Title: Synthesis and Anticoccidial Activity of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) Quinazolinone Derivatives

Volume: 7 Issue: 6

Author(s): Yuanyuan Zhang, Guangmin Chen, Yabiao Weng, Renliang Li, Yuliang Wang and Yuzhong Wang

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Keywords: 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone, Derivatives, Synthesis, Anticoccidial activity, Eimeria tenella

Abstract: A series of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone derivatives (8a-k) were designed and synthesized. Their anticoccidial activities were evaluated against Eimeria tenella in vivo. The results indicated that compounds 8a, 8b and 8e exhibited anticoccidial activity against Eimeria tenella in the chickens diet with a dose of 18 mg/Kg.

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Zhang Yuanyuan, Chen Guangmin, Weng Yabiao, Li Renliang, Wang Yuliang and Wang Yuzhong, Synthesis and Anticoccidial Activity of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) Quinazolinone Derivatives, Letters in Drug Design & Discovery 2010; 7 (6) . https://dx.doi.org/10.2174/157018010791306498