Synthesis and Biological Evaluation of Novel Bioisosteric Analogues of Dimebon™

Author(s): Alexandre Vasilevich Ivachtchenko, Eugene Borisovich Frolov, Oleg Dmitrievich Mitkin, Sergey Evgenevich Tkachenko, Alexandre Khvat.

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 6 , 2010

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Abstract:

In the present paper, we describe the synthesis and biological evaluation for a series of novel 6,9-disubstituted 2-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indoles. These compounds represent unique bioisosteric analogues of Dimebon ™ with promising biological activity against a panel of various targets including some GPCR family members.

Keywords: Dimebon™, Inhibitor, 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole, Alzheimer's disease, Parallel synthesis, GPCR, Analogues

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Article Details

VOLUME: 7
ISSUE: 6
Year: 2010
Page: [446 - 451]
Pages: 6
DOI: 10.2174/157018010791306579
Price: $58

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