Evaluation of Novel 7-(hetero)aryl-substituted Pyrazolo[1, 5-a]pyrimidines as Phosphodiesterase-4 Inhibitors
Kishore Venkata Laxmi Parsa,
Padala Lakshmi Prasunamba,
A novel series of 7-(hetero)aryl substituted-pyrazolopyrimidines, prepared via an AlCl3 induced C-C bond forming reaction of 7-chloro-5-phenyl-pyrazolo[1,5-a]pyrimidine with arenes and heteroarenes have been investigated as PDE4 inhibitors. Among all the compounds tested the 7-indolyl substituted pyrazolopyrimidine showed good inhibition of PDE 4 in vitro.
Keywords: PDE4, Rolipram, Inhibitor, Pyrazolopyrimidine
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