Current Bioinformatics

Yi-Ping Phoebe Chen
Department of Computer Science and Information Technology
La Trobe University
Melbourne
Australia

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Development of Genomics-Based Gene Expression Signature Biomarkers in Oncology and Toxicology to Facilitate Drug Discovery and Translational Medicine

Author(s): Tao Wei, Shuyu Li.

Abstract:

Biomarker identification has been a critical component in drug discovery and development. Biomarkers have been utilized in several areas such as disease diagnosis, pharmacokinetics-pharmacodynamics (PK-PD) modeling, evaluation of efficacy and toxicity to guide both pre-clinical compound selection and clinical study of candidate compounds. Recent advances in genomics and bioinformatics have created a new paradigm in the development of robust gene expression signature biomarkers, particularly for predicting toxicity and cancer drug responses. In this article, we present an overview of current progress in this arena including methodology development and applications in the drug discovery process.

Keywords: Biomarker, genomics, cancer, toxicology

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2010
Page: [109 - 117]
Pages: 9
DOI: 10.2174/157489310791268423
Price: $58