Abstract
Neural tissue has historically been regarded as having poor regenerative capacity but recent advances in the growing fields of tissue engineering and regenerative medicine have opened new hopes for the treatment of nerve injuries and neurodegenerative disorders. Adipose tissue has been shown to contain a large quantity of adult stem cells (ASC). These cells can be easily harvested with low associated morbidity and because of their potential to differentiate into multiple cell types, their use has been suggested for a wide variety of therapeutic applications. In this review we examine the evidence indicating that ASC can stimulate nerve regeneration by both undergoing neural differentiation and through the release of a range of growth factors. We also discuss some of the issues that need to be addressed before ASC can be developed as an effective cellular therapy for the treatment of neural tissue disorders.
Keywords: Nerve regeneration, adipose stem cells, nerve conduits, central nervous system, peripheral nervous system
Current Stem Cell Research & Therapy
Title: Neural Differentiation and Therapeutic Potential of Adipose Tissue Derived Stem Cells
Volume: 5 Issue: 2
Author(s): Paolo Erba, Giorgio Terenghi and Paul J. Kingham
Affiliation:
Keywords: Nerve regeneration, adipose stem cells, nerve conduits, central nervous system, peripheral nervous system
Abstract: Neural tissue has historically been regarded as having poor regenerative capacity but recent advances in the growing fields of tissue engineering and regenerative medicine have opened new hopes for the treatment of nerve injuries and neurodegenerative disorders. Adipose tissue has been shown to contain a large quantity of adult stem cells (ASC). These cells can be easily harvested with low associated morbidity and because of their potential to differentiate into multiple cell types, their use has been suggested for a wide variety of therapeutic applications. In this review we examine the evidence indicating that ASC can stimulate nerve regeneration by both undergoing neural differentiation and through the release of a range of growth factors. We also discuss some of the issues that need to be addressed before ASC can be developed as an effective cellular therapy for the treatment of neural tissue disorders.
Export Options
About this article
Cite this article as:
Erba Paolo, Terenghi Giorgio and J. Kingham Paul, Neural Differentiation and Therapeutic Potential of Adipose Tissue Derived Stem Cells, Current Stem Cell Research & Therapy 2010; 5 (2) . https://dx.doi.org/10.2174/157488810791268645
DOI https://dx.doi.org/10.2174/157488810791268645 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Epidemiology and Etiology of Alzheimer’s disease: From Genetic to Non- Genetic Factors
Current Alzheimer Research Insulin Resistance in Brain and Possible Therapeutic Approaches
Current Vascular Pharmacology 2,5-Diketopiperazines as Neuroprotective Agents
Mini-Reviews in Medicinal Chemistry Functional Food with Some Health Benefits, So Called Superfood: A Review
Current Nutrition & Food Science Hybrid Molecules Incorporating Natural Products: Applications in Cancer Therapy, Neurodegenerative Disorders and Beyond
Current Medicinal Chemistry GDNF Family Ligands: A Potential Future for Parkinson's Disease Therapy
CNS & Neurological Disorders - Drug Targets Bis(thiosemicarbazone) Metal Complexes as Therapeutics for Neurodegenerative Diseases
Current Topics in Medicinal Chemistry MicroRNAs and Physical Activity
MicroRNA Neuroprotection by Association of Palmitoylethanolamide with Luteolin in Experimental Alzheimer’s Disease Models: The Control of Neuroinflammation
CNS & Neurological Disorders - Drug Targets Established and Emerging Therapies for Huntingtons Disease
Current Molecular Medicine Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry
Current Drug Targets Amyloid-Degrading Enzymes as Therapeutic Targets in Alzheimers Disease
Current Alzheimer Research Assessing the Effectiveness of a Telemedicine Initiative in Clinical Management of Children Living with HIV/AIDS in Maharashtra, India
Current HIV Research Voltage-Gated Sodium Channel Blockers: Synthesis of Mexiletine Analogues and Homologues
Current Medicinal Chemistry Tau in Alzheimer Disease and Related Tauopathies
Current Alzheimer Research Indoles and Related Compounds as Cannabinoid Ligands
Mini-Reviews in Medicinal Chemistry Thrombomodulin – A New Target for Treating Stroke at the Crossroad of Coagulation and Inflammation
Current Medicinal Chemistry Fibrillar β-Amyloid Impairs the Late Phase of Long Term Potentiation
Current Alzheimer Research Primary Progressive Aphasia-Defining Genetic and Pathological Subtypes
Current Alzheimer Research Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons
Current Drug Targets