Abstract
Neural tissue has historically been regarded as having poor regenerative capacity but recent advances in the growing fields of tissue engineering and regenerative medicine have opened new hopes for the treatment of nerve injuries and neurodegenerative disorders. Adipose tissue has been shown to contain a large quantity of adult stem cells (ASC). These cells can be easily harvested with low associated morbidity and because of their potential to differentiate into multiple cell types, their use has been suggested for a wide variety of therapeutic applications. In this review we examine the evidence indicating that ASC can stimulate nerve regeneration by both undergoing neural differentiation and through the release of a range of growth factors. We also discuss some of the issues that need to be addressed before ASC can be developed as an effective cellular therapy for the treatment of neural tissue disorders.
Keywords: Nerve regeneration, adipose stem cells, nerve conduits, central nervous system, peripheral nervous system
Current Stem Cell Research & Therapy
Title: Neural Differentiation and Therapeutic Potential of Adipose Tissue Derived Stem Cells
Volume: 5 Issue: 2
Author(s): Paolo Erba, Giorgio Terenghi and Paul J. Kingham
Affiliation:
Keywords: Nerve regeneration, adipose stem cells, nerve conduits, central nervous system, peripheral nervous system
Abstract: Neural tissue has historically been regarded as having poor regenerative capacity but recent advances in the growing fields of tissue engineering and regenerative medicine have opened new hopes for the treatment of nerve injuries and neurodegenerative disorders. Adipose tissue has been shown to contain a large quantity of adult stem cells (ASC). These cells can be easily harvested with low associated morbidity and because of their potential to differentiate into multiple cell types, their use has been suggested for a wide variety of therapeutic applications. In this review we examine the evidence indicating that ASC can stimulate nerve regeneration by both undergoing neural differentiation and through the release of a range of growth factors. We also discuss some of the issues that need to be addressed before ASC can be developed as an effective cellular therapy for the treatment of neural tissue disorders.
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Cite this article as:
Erba Paolo, Terenghi Giorgio and J. Kingham Paul, Neural Differentiation and Therapeutic Potential of Adipose Tissue Derived Stem Cells, Current Stem Cell Research & Therapy 2010; 5 (2) . https://dx.doi.org/10.2174/157488810791268645
DOI https://dx.doi.org/10.2174/157488810791268645 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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