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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recognition of Single Stranded and Double Stranded DNA/RNA Sequences in Aqueous Medium by Small Bis-Aromatic Derivatives

Author(s): L.-M. Tumir and I. Piantanida

Volume 10, Issue 4, 2010

Page: [299 - 308] Pages: 10

DOI: 10.2174/138955710791330990

Price: $65

Abstract

The aim of this review is to summarize the most comprehensive results in the field of bis-aromatic compounds targeting DNA and RNA, whereby both aromatic units of small molecule bind to the polynucleotide by the aromatic stacking interactions. The most recent results about structure – DNA/RNA binding affinity, selectivity and biological implications are discussed for bis-intercalators, sterically restricted macrocyclic and threading bis-aromatics and intercalator – nucleobase conjugates.

Keywords: DNA and RNA binding, bis-intercalation, macrocyclic bis-intercalation, intercalator, nucleobase conjugate


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