Recognition of Single Stranded and Double Stranded DNA/RNA Sequences in Aqueous Medium by Small Bis-Aromatic Derivatives

Author(s): L.-M. Tumir, I. Piantanida.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 4 , 2010

Become EABM
Become Reviewer

Abstract:

The aim of this review is to summarize the most comprehensive results in the field of bis-aromatic compounds targeting DNA and RNA, whereby both aromatic units of small molecule bind to the polynucleotide by the aromatic stacking interactions. The most recent results about structure – DNA/RNA binding affinity, selectivity and biological implications are discussed for bis-intercalators, sterically restricted macrocyclic and threading bis-aromatics and intercalator – nucleobase conjugates.

Keywords: DNA and RNA binding, bis-intercalation, macrocyclic bis-intercalation, intercalator, nucleobase conjugate

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 10
ISSUE: 4
Year: 2010
Page: [299 - 308]
Pages: 10
DOI: 10.2174/138955710791330990
Price: $58

Article Metrics

PDF: 9